After starting the season with two wins, the Arizona Cardinals are back to square one with three back-to-back defeats after five weeks. And just when the Cardinals were hoping for a comeback in Week 6 football, things are not looking good for them, with a question about the availability of Kyler Murray. During their last game against the Titans, Murray injured his foot in the third quarter. And with the Sunday clash against the Colts only hours away, he may not be available for over a week.

As per the NFL insider Ian Rapoport, Murray is dealing with a mid-foot sprain, a version of a Lisfranc injury. So, Arizona has postponed the final decision until Sunday morning for the Week 6 game against the Colts. He missed Wednesday and Thursday practices and practiced a little on Friday only. And now the team is unsure if he will be able to play and has listed him as questionable.

This season, Murray has played well. He has completed 68.3% of his passes for 962 yards, with six touchdowns and three interceptions in five games. He has also rushed for 173 yards and one touchdown, showing he can make plays with both his arm and his legs. Murray’s ability to move and extend plays has been important for the Cardinals’ offense, which has struggled at times this year.

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His leadership is also key. He keeps the team competitive in close games. If he can’t play, it will be a major loss for both the passing and running game. The Cardinals are 2–3 and need a win to stay in the playoff race. Murray hasn’t missed a game since sitting out the first nine weeks of the 2023 season while recovering from an ACL injury.

The team is hoping he can play, but they are being careful to protect him.

Cardinals are ready with Kyler Murray’s replacement

In the meantime, Arizona is preparing veteran Jacoby Brissett in case Murray is out. He had a lot more practice than the starter. Brissett may not be as mobile as Murray, but he is good at managing the game and protecting the football. Over his career, he has thrown for 11,400 yards and 53 touchdowns. His experience could help the Cardinals stay competitive, especially against his former team, the Colts.

Early in the week, even head coach Jonathan Gannon praised the veteran. “To know that you’re one play away from your role changing, you really do got to be on the details like you’re the starter,” Gannon said after Wednesday’s practice.

Kedon Slovis, 24, has been promoted from the practice squad to the active roster. He played college football at USC, the Pittsburgh Panthers, and BYU, throwing for over 11,000 career passing yards. He went undrafted in 2024 but has impressed coaches in practice and earned a spot on the roster.

If Brissett starts, Slovis will be his backup and may get some playing time. This is a big opportunity for Slovis to gain NFL experience. Together, Brissett and Slovis give the Cardinals depth at quarterback. But the team would be hoping for a miracle and Murray to come back.